October 21, 2015
||The Harvard Faculty Club|
20 Quincy Street, Cambridge, MA, 02138, United States
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Protein Homology Modeling
The course covers protein alignments and homology modeling in MOE. The homology modeling section covers the complete sequence to structure workflow, including template searching, query alignment, adjustment of the alignment between the sequence and the template, homology model building and refinement, along with applications for assessing model quality. It uses the project search panel to explore kinase structures, and builds a model of the hERG channel, a transmembrane protein.
Application of MOE in Crystallography
The course will cover methods for evaluating, analyzing and refining protein models derived from X-ray crystallographic data. Topics related to protein structure preparation and side-chain conformational analysis and placement will be discussed. Visualization and interpretation of electron density maps for assessing protein models will be described. The 3D-RISM method for predicting and refining the placement of solvent molecules and ions in protein models will also be presented.
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