MOE Workshop Series

Europe

MANNHEIM
November 23, 2017

Location: Dorint Kongresshotel Mannheim
Friedrichsring 6, Mannheim, 68161, Germany
MAP


Registration

Title:
First Name: *
Last Name: *
Email: *
Job Title:
Organization: *
Business Type: *
Supervisor (academia only):
Country: *
Address: *
City: *
State/Province:
ZIP/Postal Code:
Phone: *

Comments:
  I would like to use my own laptop during the workshop(s).

* required field

Please check the session(s) that you would like to attend:

09:00 to 12:30 Applications of Pharmacophores in Drug Design
12:30 to 13:30 Lunch
13:30 to 17:00 Advanced Structure-Based Drug Design

Your registration will be confirmed.



 Applications of Pharmacophores in Drug Design
The course describes the application of pharmacophores in drug discovery projects and encompasses a range of topics from pharmacophore query generation to pharmacophore refinement and searching of structural databases. A new approach based on Extended Hückel Theory (EHT) for producing pharmacophore models with encoded interaction energies in the context of ligand-based and structure-based projects will be described. The generation and analysis of protein-ligand interaction fingerprints (PLIF) will be presented along with the application of PLIF for producing pharmacophore queries. A method for combining pharmacophore models and PLIF with linear and binary QSAR models for consensus modeling will also be described.

 Advanced Structure-Based Drug Design
The course describes advanced SBDD workflows in drug discovery projects and encompasses a range of topics from pharmacophore query generation to protein-ligand interaction fingerprints. More specifically, the course will cover the application of pharmacophores in the context of protein-ligand docking, scaffold replacement and R-group screening. A method for querying a 3D project database will also be presented along with the generation and analysis of protein- ligand interaction fingerprints (PLIF).


For questions, please contact:
Raul Alvarez
Senior Marketing Manager